The Consortium is formed on the initiative of the
Reorganisation of the three groups and creation of specific working groups and core facilities at each of the three sites.
Development of the first CpG-Free plasmids.
Start of the product evaluation study to assess the effectiveness of multiple gene transfer agents (GTAs) in pre-clinical studies.
Tracking Study commences.
Creation of a modular clinical plasmid design (after extensive plasmid development).
hCEFI promoter established as having superior duration of expression in pre-clinical models (after multiple promoter elements are tested).
The clinical trial plasmid pGM169 produced in Oxford.
Completion of the Tracking Study.
Commercial manufacturing of GL67A and pGM169 begins.
Testing and selection of clinical nebulisers.
Design of a mixing device for correct mixing of GL67A and pGM169.
Run-in Study commences.
Single Dose Clinical Trial (Pilot study) commences.
Completion of Single Dose Clinical Trial (Pilot study).
Extensive pre-clinical multi-dose toxicology studies completed.
CF Trust withdraws funding from the Consortium (limited funding provided to March 2012).
Consortium awarded grants from the MRC & NIHR to continue clinical trial and research programmes.
Start of multi-dose Clinical trial to assess efficacy of GL67/pGM169 formulation.
Rosie Barnes launches Just Gene Therapy to raise funds for the Consortium.
2014 - Proposed
End of multi-dose Clinical trial towards the middle of 2013.
Information for Patients on Our Clinical Trial
Consortium Members' Internal Website
Medical Futures Innovation Award 2011