• GL67A/pGM169 - the clinical trial product
• The Clinical Teams
• The Tracking Study
• The Run-in Study
• Single Dose Clinical Trial (2009-2011)
• Multi Dose Clinical Trial (2012)

The Tracking Study

In July 2006 we began to look for volunteers to help us with the Tracking Study. This involved following a CF patient during a period of lung exacerbation, whilst they were having their IV antibiotics as in-patients (or if they lived locally, at home). We took various assays from patients during this study, the results of which showed us whether a change in the assays corresponded with any clinical improvement seen in patients.

We recruited 46 volunteers aged 12 and above between the London and Edinburgh sites. The study involved requesting a few samples such as sputum and blood and asking the participant to undertake some tests such as a CT scan, exhaled breathe condensate, multiple breath washout, spirometry and nasal potential difference.

These tests were done in hospital, primarily on the first and last day of admission/course of IV antibiotics and at the follow up appointment.

We have completed the main body of the study and the data analysis is nearing completion. Preliminary data have already been presented at international CF conferences and have generated much interest within the wider respiratory field.