Clinical Programme
We started our clinical programme in July 2006
Tracking
Study
In July 2006 we began to look for volunteers
to help us with the Tracking Study. This involved following a CF
patient during a period of lung exacerbation, whilst they were having
their IV antibiotics as in-patients (or if they lived locally, at
home). We took various assays from patients during this study, the
results of which showed us whether a change in the assays corresponded
with any clinical improvement seen in patients.
We recruited 46 volunteers aged 12 and above between the London and Edinburgh sites. The study involved requesting a few samples such as sputum and blood and asking the participant to undertake some tests such as CT scan, exhaled breathe condensate, multiple breath washout, spirometry and nasal potential difference. These tests were done in hospital, primarily on the first and last day of admission/course of IV antibiotics and at the follow up appointment.
Progress
report
We have completed the main body of the study but we are continuing to
collect data on some assays. The data analysis is nearing completion,
but preliminary data have already been presented at international CF
conferences and have generated much interest within the wider
respiratory field.