Current Research
Improving Non-Viral Gene Transfer
Agents
Finding or developing new, better non-viral gene transfer agents is one
way that gene transfer could be improved and to this aim we have adopted
a combined approach that involves both procurement and in-house
development of new GTAs. We have established high throughput core
facilities in which the in vivo efficiency of gene transfer
agents can be assessed.
In-house development includes adding
peptides and sugars in various ways to existing GTA in order to target
them to the correct cells, increase their uptake and guide their path
through the cell to the nucleus.