Monday, June 25th 2012
New Consortium publication 'CpG-free plasmid expression cassettes for cystic fibrosis gene therapy' is published in Biomaterials.
This paper essentially describes the steps taken to optimise the design of the clinical trial plasmid.
Our plasmids have a simple modular design allowing us to change functional elements really easily. This paper describes how we evaluated the individual components of the plasmid to develop what has ultimately become our clinical trial plasmid pGM169.