New Review Article, Griesenbach et al., 2015

Thursday, April 2nd 2015

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'Cystic Fibrosis Gene Therapy in the UK and elsewhere' in  a new review article published in Human Gene Therapy by Griesenbach et al.

The review looks at the history of CF gene therapy over the past 20 years and considers the practical considerations, barriers and challenges to the approach.

The various different type of vectors that ourselves and the field have used are also reviewed.

The publication details can be viewed here: Griesenbach et al., 2015.


Figure 1: Ciliated human airway epithelial cells – target cell for CF Gene Therapy. The dense ciliary border on airway epithelial cells is a significant extracellular barrier to CF gene therapy. Cilia are stained with an anti-tubulin β antibody (green). Nuclei are stained with DAPI (blue). Picture courtesy of Dr M Wasowicz (Department of Gene Therapy, Imperial College)


Light microscope image of a human airway liquid interface cultures. Dark patches are mucous.


A frozen vial of GL67A (left) and a frozen vial of pGM169 plasmid DNA (right)