Latest News

Al Jazeera Feature on the Clinical Trial

Al Jazeera's Dr Elizabeth Healey was in London recently to produce a feature on the results of our recent clinical trial. She interviewed Prof Jane Davies & Prof Uta Griesenbach about the progress we have made to date and plans for the future of this programme.

1 year ago

 

 

Prof Eric Alton Interview on Imperial College Website

'The long road to developing gene therapy' - Prof Eric Alton spoke with Andrew Czyzewski from Imperial College's Communications and Public Affairs office to discuss the results of our clinical trial. The interview covers why and how Eric became involved with with CF and gene therapy for CF in particular. Other areas covered include why it has taken so long for this research to show such promise and where next for our clinical programme.

1 year ago

 

 

Cystic Fibrosis Gene Therapy Clinical Trial Demonstrates Beneficial Effect on Lung Function

The Consortium are pleased to announce the publication of the results from our MD gene therapy clinical in the Journal Lancet Respiratory Medicine. The trial is the first ever to show that repeated doses of a gene therapy can have a meaningful effect on the disease and change the lung function of patients.The clinical trial reached its primary endpoint with patients who received therapy having a significant, if modest benefit in lung function compared with those receiving a placebo.

1 year ago

 

 

Media Coverage of the Clinical Trial Results

Here is a collection of stories in the press following the publication of our clinical trial results. We would like to thank these journalists for taking time to cover this story.

1 year ago

 

 

CF Trust Announces £500,000 of Support for the Consortium

The Cystic Fibrosis Trust has today announced it is committing £500,000 to the UKCFGTC over the next two years to support the infrastructure of the GTC to allow further development of its gene therapy programme for people with cystic fibrosis.

2 years ago

 

 

UKCFGTC at BSGCT Public Education Day, Glasgow 9 June

The Consortium will be represented at this year’s BSGCT Public Education day on Tuesday 9 June at the Technology and Innovation Centre, University of Strathclyde. This is a free event that takes place before the full BSGCT Conference. It is aimed at all members of the public and offers the chance to hear from and meet leading figures in the field of gene and cell therapy.

2 years ago

 

 

Clinical Trial Results Presentation, Timetable and Venue Information

The timetable and venue information for the Clinical Trial Results Meeting are now available. The meeting will start at 11:00 on Saturday 30 May. The London venue is the Alexander Fleming Building, Imperial College, London & the live link to Edinburgh will be held in the The MRC Institute of Genetics and Molecular Medicine at the Western General Hospital.

2 years ago

 

 

Gene Therapy Clinical Trial Results to be Announced on 30th May

We wanted to update you on the Multidose Gene Therapy Trial. This was a complex trial requiring extensive data analysis, but we now have the results, which have been submitted for peer review. In collaboration with the CF Trust, we will be holding an open meeting to present the data and address questions. This will be held in London on Saturday May 30th, and will be live-streamed for those unable to attend.

2 years ago

 

 

Dr Deborah Gill to Address Broken Arrow Conference in Toronto

In a late change to the original agenda, Dr Deborah Gill will be attending the 'Broken Arrow Conference' in Toronto this weekend (02 May - 03 May). The conference is organised by Cystic Fibrosis Canada. The conference's theme this year is Gene Discovery to Personalized Medicine and leading researchers in the CF community are presenting.

2 years ago

 

 

Four Consortium Abstracts at the 2015 ASGCT Conference

The 18th American Society of Gene & Cell Therapy Conference takes place in New Orleans next month (13 to 16 May). The Conference has become the main global event for the gene therapy community with around 2500 scientists and clinicians attending. A small group of Consortium scientists are heading out to represent us.

2 years ago

 

 

New Review Article, Griesenbach et al., 2015

'Cystic Fibrosis Gene Therapy in the UK and elsewhere' in a new review article published in Human Gene Therapy by Griesenbach et al. The review looks at the history of CF gene therapy over the past 20 years and considers the practical considerations, barriers and challenges to the approach. The various different type of vectors that ourselves and the field have used are also reviewed.

2 years ago

 

 

Gene Therapy for Cystic Fibrosis Public Lecture in Reading

Café Scientifique – Gene Therapy for Cystic Fibrosis. Dr Deborah Gill and Dr Steve Hyde are presenting a talk tonight (12 March 2015 @ 19:00) at Bradfield College in Reading. The talk is open to the public and will be a general presentation on CF gene therapy.

2 years ago

 

 

Four Consortium Abstracts at BTS 2014 Winter Meeting

The Consortium will be represented at this week's British Thoracic Society's Winter Meeting in London. Four Abstracts are being presented, 3 are based on background work to our Multi-Dose clinical trial and one is based on our ongoing development of a Lentiviral Vector for CF Lung Disease.

2 years ago

 

 

Gene Therapy Multi Dose Clinical Trial Update

Gene Therapy Multi-Dose Clinical Trial Update: As you will know we had hoped to announce the outcome of the Multidose Gene Therapy Trial at the upcoming North American CF Conference (NACFC).

2 years ago

 

 

New Publication, Davies et al., 2014

Lee Davies evaluated a range of suitable, commercially available nebulisers for use in our clinical trial.

3 years ago

 

 

 

Proposed 3D model of the CFTR protein.

 

Sheep lung parenchyma (cell nuclei blue) transduced with an adenoviral vector (green).

 

Mouse lung large airway (cell nuclei blue) transduced with an adenoviral vector (green).

 

Pellets of DNA following precipitation.