Papers 3

  1. Aerosol delivery of DNA/liposomes to the lung for cystic fibrosis gene therapy.
    Davies LA et al., Hum Gene Ther Clin Dev. 2014 Jun;25(2):97-107. doi: 10.1089/humc.2014.019. Epub 2014 May 27.
  2. A novel mixing device for the reproducible generation of nonviral gene therapy formulations.
    Davies LA et al., Biotechniques. 2010 Sep;49(3):666-8. doi: 10.2144/000113498.
  3. Adenovirus-mediated in utero expression of CFTR does not improve survival of CFTR knockout mice.
    Davies LA et al., Mol Ther. 2008 May;16(5):812-8. doi: 10.1038/mt.2008.25. Epub 2008 Mar 11.

Abstracts 9

  1. Long-Term Stability of Aqueous pDNA/PEI Complexes.
    Nunez-Alonso GA et al.,The American Society of Gene Therapy Annual Conference (2007)
  2. Repeated Exposure to pDNA/PEI Aerosols Results in Minimal Detectable Toxicity in the Mouse Lungs .
    Nunez-Alonso GA et al.,The American Society of Gene Therapy Annual Conference (2009)
  3. Optimisation of Aerosol Delivery of Lipid/DNA Complexes for Clinical Studies.
    Davies LA et al.,The American Society of Gene Therapy Annual Conference (2008)
  4. A Novel Mixing Device for the Reproducible Manufacture of Non-Viral Gene Therapy Formulations.
    Davies LA et al.,The American Society of Gene Therapy Annual Conference (2009)
  5. Concentrated PEI Formulations Retain Biological Efficacy Following Long-Term Storage at 4C.
    Davies LA et al.,The American Society of Gene and Cell Therapy Annual Conference (2010)
  6. Aerosol Characteristics of DNA/lipid Formulations for Gene Therapy Clinical Studies.
    Gill DR et al.,The North American Cystic Fibrosis Conference (2008)
  7. Influence of the Human and Murine CMV Enhancer on the Duration of Expression from CpG-Free pDNA Vectors in the Mouse Lung.
    Green A-M et al.,The American Society of Gene Therapy Annual Conference (2007)
  8. Adenovirus-mediated in utero expression of CFTR does not improve survival of CFTR knockout mice.
    Davies L et al.,The British Society of Gene Therapy Annual Conference (2008)
  9. Towards Gene Therapy for Cystic Fibrosis: Bio-Distribution of GL67A/pGM169 DNA and mRNA Following Aerosol Delivery to the Mouse Lung.
    Pringle IA et al.,The American Society of Gene Therapy Annual Conference (2008)

 

Proposed 3D model of the CFTR protein.

 

DNA fragments being cut from an agarose gel exposed to UV.