Latest News

New Publication, Alton et al., 2015 - Single Dose Clinical Trial

The results of the Consortium's first - single dose clinical trial of our GL67a/pGM169 formulation have been published. This trial preceeded our multi dose clinical trial the results of which were published in July.The aim of the Pilot study was to assess the safety of a single dose of the Wave 1 product. A total of 35 patients received a single nebulised dose of GL67a/pGM169 in either a 5 ml, 10 ml or 20 ml volume.

5 years ago



Videos from UK CF Conference Now Available

The UK Cystic Fbrosis Conference took place a couple of weeks ago in Manchester, organised by the CF Trust. Thanks to their excellent media team you can watch the entire conference on line. The Consortium was represented by Prof Jane Davies who gave a presentation on using Lung Clearance Index in clinical trials and Prof Eric Alton presented the data from our clinical trial.

5 years ago



Consortium Represented at NACFC 2015 in Phoenix

The 29th North American Cystic Fibrosis Conference starts tomorrow (08/10) in Phoenix. The Consortium will be well represented in what promises to be an exciting conference following a landmrk year for CF research. The Vertex clinical trial data and our own gene therapy clinical trial results will be prominently discussed. The Consortium has four abstracts being presented at the meeting.

5 years ago



Flutterby FUNdraisers Meet Consortium Scientists and Present Cheque for £18,000

On Saturday 3rd October, the UKCFGTC’s gene therapy group at the Centre for Genomic and Experimental Medicine was delighted to welcome thirteen supporters of the Flutterby FUNdraisers. Following a lab tour, presentations on the Consortium's work and some practical demonstrations, The visit concluded with an informal lunch and a photo opportunity at which the UKCFGTC were presented with a generous donation of £18,000 raised at Flutterby FUNdraiser events.

5 years ago



Prof Deborah Gill to Present at The European Society of Gene and Cell Therapy Conference

The annual European Society of Gene and Cell Therapy Conference takes place in Helsinki this weeken (09-17 to 09-20). The Consortium will be represented by Prof Deborah Gill who will present the results of out MD Clinical Trial. This marks the first time the results of the trial have been presented to a gene therapy specific audience since the publication of the results in July.

5 years ago



Al Jazeera Feature on the Clinical Trial

Al Jazeera's Dr Elizabeth Healey was in London recently to produce a feature on the results of our recent clinical trial. She interviewed Prof Jane Davies & Prof Uta Griesenbach about the progress we have made to date and plans for the future of this programme.

5 years ago



Prof Eric Alton Interview on Imperial College Website

'The long road to developing gene therapy' - Prof Eric Alton spoke with Andrew Czyzewski from Imperial College's Communications and Public Affairs office to discuss the results of our clinical trial. The interview covers why and how Eric became involved with with CF and gene therapy for CF in particular. Other areas covered include why it has taken so long for this research to show such promise and where next for our clinical programme.

5 years ago



Cystic Fibrosis Gene Therapy Clinical Trial Demonstrates Beneficial Effect on Lung Function

The Consortium are pleased to announce the publication of the results from our MD gene therapy clinical in the Journal Lancet Respiratory Medicine. The trial is the first ever to show that repeated doses of a gene therapy can have a meaningful effect on the disease and change the lung function of patients.The clinical trial reached its primary endpoint with patients who received therapy having a significant, if modest benefit in lung function compared with those receiving a placebo.

5 years ago



Media Coverage of the Clinical Trial Results

Here is a collection of stories in the press following the publication of our clinical trial results. We would like to thank these journalists for taking time to cover this story.

5 years ago



CF Trust Announces £500,000 of Support for the Consortium

The Cystic Fibrosis Trust has today announced it is committing £500,000 to the UKCFGTC over the next two years to support the infrastructure of the GTC to allow further development of its gene therapy programme for people with cystic fibrosis.

5 years ago



UKCFGTC at BSGCT Public Education Day, Glasgow 9 June

The Consortium will be represented at this year’s BSGCT Public Education day on Tuesday 9 June at the Technology and Innovation Centre, University of Strathclyde. This is a free event that takes place before the full BSGCT Conference. It is aimed at all members of the public and offers the chance to hear from and meet leading figures in the field of gene and cell therapy.

5 years ago



Clinical Trial Results Presentation, Timetable and Venue Information

The timetable and venue information for the Clinical Trial Results Meeting are now available. The meeting will start at 11:00 on Saturday 30 May. The London venue is the Alexander Fleming Building, Imperial College, London & the live link to Edinburgh will be held in the The MRC Institute of Genetics and Molecular Medicine at the Western General Hospital.

5 years ago



Gene Therapy Clinical Trial Results to be Announced on 30th May

We wanted to update you on the Multidose Gene Therapy Trial. This was a complex trial requiring extensive data analysis, but we now have the results, which have been submitted for peer review. In collaboration with the CF Trust, we will be holding an open meeting to present the data and address questions. This will be held in London on Saturday May 30th, and will be live-streamed for those unable to attend.

6 years ago



Dr Deborah Gill to Address Broken Arrow Conference in Toronto

In a late change to the original agenda, Dr Deborah Gill will be attending the 'Broken Arrow Conference' in Toronto this weekend (02 May - 03 May). The conference is organised by Cystic Fibrosis Canada. The conference's theme this year is Gene Discovery to Personalized Medicine and leading researchers in the CF community are presenting.

6 years ago



Four Consortium Abstracts at the 2015 ASGCT Conference

The 18th American Society of Gene & Cell Therapy Conference takes place in New Orleans next month (13 to 16 May). The Conference has become the main global event for the gene therapy community with around 2500 scientists and clinicians attending. A small group of Consortium scientists are heading out to represent us.

6 years ago




Purifying mRNA from tissue samples.


E.coli from a large scale industrial production of our clinical trial plasmid pGM169.


A frozen vial of GL67A (left) and a frozen vial of pGM169 plasmid DNA (right)


Sheep lung parenchyma (cell nuclei blue) transduced with an adenoviral vector (green).