Latest News

New Review Article, Griesenbach et al., 2015

'Cystic Fibrosis Gene Therapy in the UK and elsewhere' in a new review article published in Human Gene Therapy by Griesenbach et al. The review looks at the history of CF gene therapy over the past 20 years and considers the practical considerations, barriers and challenges to the approach. The various different type of vectors that ourselves and the field have used are also reviewed.

6 years ago



Gene Therapy for Cystic Fibrosis Public Lecture in Reading

Café Scientifique – Gene Therapy for Cystic Fibrosis. Dr Deborah Gill and Dr Steve Hyde are presenting a talk tonight (12 March 2015 @ 19:00) at Bradfield College in Reading. The talk is open to the public and will be a general presentation on CF gene therapy.

6 years ago



Four Consortium Abstracts at BTS 2014 Winter Meeting

The Consortium will be represented at this week's British Thoracic Society's Winter Meeting in London. Four Abstracts are being presented, 3 are based on background work to our Multi-Dose clinical trial and one is based on our ongoing development of a Lentiviral Vector for CF Lung Disease.

6 years ago



Gene Therapy Multi Dose Clinical Trial Update

Gene Therapy Multi-Dose Clinical Trial Update: As you will know we had hoped to announce the outcome of the Multidose Gene Therapy Trial at the upcoming North American CF Conference (NACFC).

6 years ago



New Publication, Davies et al., 2014

Lee Davies evaluated a range of suitable, commercially available nebulisers for use in our clinical trial.

6 years ago



Ian Pringle Receives ASGCT Travel Grant Award

Consortium Scientist Dr Ian Pringle received a $500 award to attend this year's ASGCT Conference in Washington DC.

6 years ago



Young Investigator Award for Consortium PhD Student

Cathy Oliveira one of our PhD students at Oxford has received a Young Investigator Award to attend the 3rd Minicircle & DNA Vector Conference in Bielefeld, Germany, 8-9 May.

7 years ago



Hype Cycles and Technological Maturity - BSGCT Presentation

Natasha Davie, one of our PhD students in Oxford presented a different kind of poster at the 2014 British Society for Gene and Cell Therapy in London. Natasha is researching gene therapy as a whole and trying to gain an understanding as to why greater progress has not been made with this technology to date.

7 years ago



Wave II Update

Transcriptional control of transgene expression is crucial to successful gene therapy, yet few promoter/enhancer combinations have been tested in clinical trials. We created a simple, desktop computer database and populated it with promoter sequences from publicly available sources.

7 years ago



Clinical Trial Update

Clinical Trial Update. The Wave 1 Clinical Trial (CF gene delivered by liposomes) is going well. We were able to recruit all the patients needed from CF Centres across the UK. Approximately half the patients have received all the 12 doses of gene therapy or placebo given at monthly intervals.

7 years ago



Consortium scientists take part in CF Unite Event

Dr Uta Griesenbach & Dr Ian Pringle were in Nottingham today to take part in an event organised by CF Unite. Ian gave a presenation on CF Genes & Genetics and Uta talked about the ongoing work of the Consortium. Cystic Fibrosis Unite aims to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition. CFUnite has been created by people with CF, parents of children with CF, researchers and clinicians.

7 years ago



CF Trust Awards Consortium £300,000 for Wave II Research

The CF Trust has awarded the Consortium £ 308,000 towards our Wave II Lentiviral Research Programme.

8 years ago



Prof David Porteous OBE

Congratulations to Prof David Porteous who has been awarded an OBE for Services to Science.

8 years ago



New Publication, Pringle et al., 2012

New Consortium publication 'Rapid identification of novel functional promoters for gene therapy' is published in the Journal of Molecular Medicine. This paper results from a series of studies aiming to identify novel promoters for gene therapy. Promoters are vital to all gene therapy vectors as they are responsible for generating gene expression.

8 years ago



New Publication Describes Creation of pGM169

New Consortium publication 'CpG-free plasmid expression cassettes for cystic fibrosis gene therapy' is published in Biomaterials. This paper essentially describes the steps taken to optimise the design of the clinical trial plasmid.

8 years ago




A frozen vial of GL67A (left) and a frozen vial of pGM169 plasmid DNA (right)


Mouse lung large airway (cell nuclei blue) transduced with an adenoviral vector (green).


Large scale lentivirus production in suspension culture.


DNA fragments being cut from an agarose gel exposed to UV.