Papers 15

  1. Binding protein-dependent transport systems.
    Higgins CF et al., J Bioenerg Biomembr. 1990 Aug;22(4):571-92.
  2. Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein.
    Gill DR et al., Cell. 1992 Oct 2;71(1):23-32.
  3. Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy.
    Hyde SC et al., Nature. 1993 Mar 18;362(6417):250-5.
  4. Towards gene therapy for cystic fibrosis: a clinical progress report.
    Alton EW et al., Gene Ther. 1998 Mar;5(3):291-2.
  5. Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.
    Gill DR et al., Gene Ther. 2001 Oct;8(20):1539-46.
  6. Chloride secretion in the trachea of null cystic fibrosis mice: the effects of transfection with pTrial10-CFTR2.
    MacVinish LJ et al., J Physiol. 1997 Mar 15;499 ( Pt 3):677-87.
  7. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein.
    Valverde MA et al., Nature. 1992 Feb 27;355(6363):830-3.
  8. Drug efflux mediated by the human multidrug resistance P-glycoprotein is inhibited by cell swelling.
    Sardini A et al., J Cell Sci. 1994 Dec;107 ( Pt 12):3281-90.
  9. Specific inhibitors distinguish the chloride channel and drug transporter functions associated with the human multidrug resistance P-glycoprotein.
    Mintenig GM et al., Receptors Channels. 1993;1(4):305-13.
  10. The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.
    Trezise AE et al., EMBO J. 1992 Dec;11(12):4291-303.
  11. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport.
    Hyde SC et al., Nature. 1990 Jul 26;346(6282):362-5.
  12. A second dose of a CFTR cDNA-liposome complex is as effective as the first dose in restoring cAMP-dependent chloride secretion to null CF mice trachea.
    Goddard CA et al., Gene Ther. 1997 Nov;4(11):1231-6.
  13. Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.
    Zhang JJ et al., J Clin Invest. 1994 Oct;94(4):1690-7.
  14. Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.
    Hyde SC et al., Gene Ther. 2000 Jul;7(13):1156-65.
  15. A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.
    Gill DR et al., Gene Ther. 1997 Mar;4(3):199-209.

 

Light microscope image of a human airway liquid interface cultures. Dark patches are mucous.

 

A pellet of E.coli containing a plasmid expressing a pink fluorescent protein.

 

A cake that only some of us got to enjoy!