Latest News

New Publication - Gelinas et al 2017 - Media Supplements to Improve Lentiviral Vector Production Yields

A new Consortium publication, out today in the journal, Scientific reports looks at the use of media supplementation to improve lentiviral vector production.

19 days ago

 

 

Gene Therapy Funding Update

The UKCFGTC is pleased to announce that we have received £2.7M to undertake a Phase 1/2a nose trial in CF patients using our Wave 2 product, delivering the CFTR gene using a novel lentivirus. This latest support, which builds on many years of gene therapy funding from the Cystic Fibrosis Trust, the National Institute for Health Research (NIHR) and the Medical Research Council (MRC), has been awarded by the Wellcome Trust/Department of HICF fund.

22 days ago

 

 

Consortium Student Live Facebook Interview from ASGCT

Jack Tan, one our students, will giving an interview later on today live from the The American Society of Gene & Cell Therapy Annual Meeting in Washington DC. Jack is a final year student at Wolfson College Oxford and he is funded by a scholarship from the Malaysian Government. His work is not directly related to CF gene therapy, instead he has been working on projects relating to novel immunisation strategies for Flu and Ebola.

4 months ago

 

 

Tessa Morrish Awarded MBE

We were delighted to see that Tessa Morrish, one of the UKCFGTC biggest supporters over many years, received a well-deserved MBE for her services to charity. Tessa’s support, encouragement and perseverance has been hugely appreciated and were well exemplified by Tessa even managing to mention gene therapy to Prince Charles during the award ceremony.

6 months ago

 

 

New Publication - Preparation for a Lentivirus Gene Therapy Clinical Trial in Cystic Fibrosis

New Publication - Preparation for a Lentivirus Gene Therapy Clinical Trial in Cystic Fibrosis

10 months ago

 

 

EIT Health Transition Fellowship for Consortium Student

Consortium PhD Student, Jean-Francois Glinas (Keble College, Oxford) has secured an EIT Health Transition Fellowship. The scheme focuses on providing funding to close the gap between completion of a doctoral thesis and obtaining seed funding for innovative idea based on DPhil research. Jean-Francois, a DPhil student with Prof Deborah Gill and Prof Steve Hyde in Oxford, has secured a Gold Award worth 27,500 to further his research on enhancing lentiviral vector production for gene therap

11 months ago

 

 

Prof Jane Davies Podcast with Lancet Respiratory Medicine

August's issues of Lancet Respiratory Medicine is a special issue on Cystic Fibrosis. Accompanying the issue is a podcast by our very own Prof Jane Davies. There are articles on personalized medicine in CF, classification of CF mutations and some latest data from ongoing studies with Orkambi.

1 year ago

 

 

New Report on Multi Dose Clinical Trial Published

A new in depth report on our MD clinical trial has been published by the National Institute for Health Research. The report is published in 'Efficacy and Mechanism Evaluation' a journal for studies funded by the NIHR via its EME programme. The results of the clinical trial were originally published last summer (Alton et al., 2015) and this report contains no new data. However it represents a more extensive account of the clinical trial protocol and the raw data generated.

1 year ago

 

 

Consortium off to the BSGCT 2016

Tomorrow (Friday 15 April) marks the British Society for Gene and Cell Therapy Annual Conference at the ICH in London. On alternate years the BSGCT conference is a one day event and this year the focus is on adeno associated virus vectorology. The programme has the title 'AAV in 2016: Biology, vector design and implementation into human gene therapy' and it promises to be a very interesting day.

1 year ago

 

 

Flutterby FUNdraisers Donate by Text

GENE16 to 70070. Our friends at Flutterby FUNdraisers have setup a text to donate number. They raise money for the Consortium and now you can donate by simply texting GENE16 to 70070. 100% of your donation goes to Flutterby FUNdraisers.

1 year ago

 

 

Consortium Scientists Take on Charity Cycle Challenge

On 30 April two Consortium Scientists will emerge from their dark lab and struggling against the daylight they will throw off their stained lab coats to take on the epic Callander Cycle Challenge 2016! They are taking part in this event to raise money for the Flutterby FUNdraisers, a charity setup to raise money for the Consortium's work.

1 year ago

 

 

New Publication - Not All Transgene Sequences Are Equal

A new publication by Bazzani, Pringle et al looks at different plasmid vector designs to try an understand what factors are important and what is not. It follows on from a series of other papers that we have produced demonstrating that plasmids completely free of CpG dinucleotides result in long term expression in our model systems.

1 year ago

 

 

New Publication, Alton et al., 2015 - Single Dose Clinical Trial

The results of the Consortium's first - single dose clinical trial of our GL67a/pGM169 formulation have been published. This trial preceeded our multi dose clinical trial the results of which were published in July.The aim of the Pilot study was to assess the safety of a single dose of the Wave 1 product. A total of 35 patients received a single nebulised dose of GL67a/pGM169 in either a 5 ml, 10 ml or 20 ml volume.

1 year ago

 

 

Videos from UK CF Conference Now Available

The UK Cystic Fbrosis Conference took place a couple of weeks ago in Manchester, organised by the CF Trust. Thanks to their excellent media team you can watch the entire conference on line. The Consortium was represented by Prof Jane Davies who gave a presentation on using Lung Clearance Index in clinical trials and Prof Eric Alton presented the data from our clinical trial.

1 year ago

 

 

Consortium Represented at NACFC 2015 in Phoenix

The 29th North American Cystic Fibrosis Conference starts tomorrow (08/10) in Phoenix. The Consortium will be well represented in what promises to be an exciting conference following a landmrk year for CF research. The Vertex clinical trial data and our own gene therapy clinical trial results will be prominently discussed. The Consortium has four abstracts being presented at the meeting.

1 year ago

 

 

 

A cake that only some of us got to enjoy!

 

DNA fragments being cut from an agarose gel exposed to UV.

 

Pellets of DNA following precipitation.

 

Light microscope image of a human airway liquid interface cultures. Dark patches are mucous.