Latest News

Tessa Morrish Awarded MBE

We were delighted to see that Tessa Morrish, one of the UKCFGTC biggest supporters over many years, received a well-deserved MBE for her services to charity. Tessa’s support, encouragement and perseverance has been hugely appreciated and were well exemplified by Tessa even managing to mention gene therapy to Prince Charles during the award ceremony.

23 days ago

 

 

New Publication - Preparation for a Lentivirus Gene Therapy Clinical Trial in Cystic Fibrosis

New Publication - Preparation for a Lentivirus Gene Therapy Clinical Trial in Cystic Fibrosis

4 months ago

 

 

EIT Health Transition Fellowship for Consortium Student

Consortium PhD Student, Jean-Francois Gélinas (Keble College, Oxford) has secured an EIT Health Transition Fellowship. The scheme focuses on providing funding to close the gap between completion of a doctoral thesis and obtaining seed funding for innovative idea based on DPhil research. Jean-Francois, a DPhil student with Prof Deborah Gill and Prof Steve Hyde in Oxford, has secured a Gold Award worth €27,500 to further his research on enhancing lentiviral vector production for gene therap

5 months ago

 

 

Prof Jane Davies Podcast with Lancet Respiratory Medicine

August's issues of Lancet Respiratory Medicine is a special issue on Cystic Fibrosis. Accompanying the issue is a podcast by our very own Prof Jane Davies. There are articles on personalized medicine in CF, classification of CF mutations and some latest data from ongoing studies with Orkambi.

7 months ago

 

 

New Report on Multi Dose Clinical Trial Published

A new in depth report on our MD clinical trial has been published by the National Institute for Health Research. The report is published in 'Efficacy and Mechanism Evaluation' a journal for studies funded by the NIHR via its EME programme. The results of the clinical trial were originally published last summer (Alton et al., 2015) and this report contains no new data. However it represents a more extensive account of the clinical trial protocol and the raw data generated.

8 months ago

 

 

Consortium off to the BSGCT 2016

Tomorrow (Friday 15 April) marks the British Society for Gene and Cell Therapy Annual Conference at the ICH in London. On alternate years the BSGCT conference is a one day event and this year the focus is on adeno associated virus vectorology. The programme has the title 'AAV in 2016: Biology, vector design and implementation into human gene therapy' and it promises to be a very interesting day.

11 months ago

 

 

Flutterby FUNdraisers Donate by Text

GENE16 to 70070. Our friends at Flutterby FUNdraisers have setup a text to donate number. They raise money for the Consortium and now you can donate by simply texting GENE16 to 70070. 100% of your donation goes to Flutterby FUNdraisers.

11 months ago

 

 

Consortium Scientists Take on Charity Cycle Challenge

On 30 April two Consortium Scientists will emerge from their dark lab and struggling against the daylight they will throw off their stained lab coats to take on the epic Callander Cycle Challenge 2016! They are taking part in this event to raise money for the Flutterby FUNdraisers, a charity setup to raise money for the Consortium's work.

11 months ago

 

 

New Publication - Not All Transgene Sequences Are Equal

A new publication by Bazzani, Pringle et al looks at different plasmid vector designs to try an understand what factors are important and what is not. It follows on from a series of other papers that we have produced demonstrating that plasmids completely free of CpG dinucleotides result in long term expression in our model systems.

11 months ago

 

 

New Publication, Alton et al., 2015 - Single Dose Clinical Trial

The results of the Consortium's first - single dose clinical trial of our GL67a/pGM169 formulation have been published. This trial preceeded our multi dose clinical trial the results of which were published in July.The aim of the Pilot study was to assess the safety of a single dose of the Wave 1 product. A total of 35 patients received a single nebulised dose of GL67a/pGM169 in either a 5 ml, 10 ml or 20 ml volume.

1 year ago

 

 

Videos from UK CF Conference Now Available

The UK Cystic Fbrosis Conference took place a couple of weeks ago in Manchester, organised by the CF Trust. Thanks to their excellent media team you can watch the entire conference on line. The Consortium was represented by Prof Jane Davies who gave a presentation on using Lung Clearance Index in clinical trials and Prof Eric Alton presented the data from our clinical trial.

1 year ago

 

 

Consortium Represented at NACFC 2015 in Phoenix

The 29th North American Cystic Fibrosis Conference starts tomorrow (08/10) in Phoenix. The Consortium will be well represented in what promises to be an exciting conference following a landmrk year for CF research. The Vertex clinical trial data and our own gene therapy clinical trial results will be prominently discussed. The Consortium has four abstracts being presented at the meeting.

1 year ago

 

 

Flutterby FUNdraisers Meet Consortium Scientists and Present Cheque for £18,000

On Saturday 3rd October, the UKCFGTC’s gene therapy group at the Centre for Genomic and Experimental Medicine was delighted to welcome thirteen supporters of the Flutterby FUNdraisers. Following a lab tour, presentations on the Consortium's work and some practical demonstrations, The visit concluded with an informal lunch and a photo opportunity at which the UKCFGTC were presented with a generous donation of £18,000 raised at Flutterby FUNdraiser events.

1 year ago

 

 

Prof Deborah Gill to Present at The European Society of Gene and Cell Therapy Conference

The annual European Society of Gene and Cell Therapy Conference takes place in Helsinki this weeken (09-17 to 09-20). The Consortium will be represented by Prof Deborah Gill who will present the results of out MD Clinical Trial. This marks the first time the results of the trial have been presented to a gene therapy specific audience since the publication of the results in July.

1 year ago

 

 

Al Jazeera Feature on the Clinical Trial

Al Jazeera's Dr Elizabeth Healey was in London recently to produce a feature on the results of our recent clinical trial. She interviewed Prof Jane Davies & Prof Uta Griesenbach about the progress we have made to date and plans for the future of this programme.

1 year ago

 

 

 

Light microscope image of a human airway liquid interface cultures. Dark patches are mucous.

 

Mouse lung large airway (cell nuclei blue) transduced with an adenoviral vector (green).

 

DNA fragments being cut from an agarose gel exposed to UV.

 

A cake that only some of us got to enjoy!