Current and Novel Antimicrobial Approaches, in Cystic fibrosis in the 21st century (2006).

Davies JC

Karger

Antibiotics are the mainstay of treatment for pulmonary disease in CF.

Along with improved airway clearance techniques and nutrition, the availability (and aggressive use) of effective antimicrobials has been a major contributing factor in the improved health and prognosis of patients today.

However, significant problems still exist: bacteria develop resistance, either via genetic mutation or biofilm formation; the huge numbers of antibiotics administered to patients pose a burden on them, both in terms of time and toxicity; and most of the current strategies treat rather than prevent infection.

For all these reasons, new approaches would be highly desir- able.This chapter will review recent developments in conventional antimicrobial approaches and go on to highlight some of the research areas with promise.

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