Eric Alton on BBC Today Programme

Friday, March 16th 2012

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Eric Alton'Exciting' new cystic fibrosis therapy, BBC News.

Professor Eric Alton, UK Cystic Fibrosis Gene Therapy Consortium Coordinator from Imperial College, talks to the Today programme's Justin Webb about the multi-dose gene therapy trial.

The professor leading a trial in cystic fibrosis treatment said that there is "huge excitement" about a new type of gene therapy. 

Professor Eric Alton, UK Cystic Fibrosis Gene Therapy Consortium Coordinator from Imperial College, told the Today programme's Justin Webb that his team is "excited and enthused" but insisted that it was important not to hype the potential breakthrough. 

The trial is being funded by the National Institute for Health Research and the Medical Research Council and it is hoped that it will ultimately lead to a cure for the inherited disorder which affects around 9,500 people in the UK and 90,000 around the world. 

Professor Alton told the Today programme's Justin Webb that, "The biggest snag is the evolution of the lungs which, as well as preventing germs and infections from getting in, also stop gene therapy from being effective, so his team has spent the last decade trying to find tricks to slip the gene in."

"This is difficult science that needs to be built up gradually," he said. But if it is successful the scientists involved could "book their tickets to Stockholm to pick up their Nobel Prize".

http://news.bbc.co.uk/today/hi/today/newsid_9706000/9706384.stm

"The biggest snag is the evolution of the lungs which, as well as preventing germs and infections from getting in, also stop gene therapy from being effective, so his team has spent the last decade trying to find tricks to slip the gene in."

Eric Alton


 

A cake that only some of us got to enjoy!

 

Pellets of DNA following precipitation.

 

Sheep lung parenchyma (cell nuclei blue) transduced with an adenoviral vector (green).