Gene therapy progress and prospects: cystic fibrosis.

Griesenbach U, Geddes DM, Alton EW

Gene Therapy

Gene Ther. 2006 Jul;13(14):1061-7.

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Our first review on progress and prospects in cystic fibrosis (CF) gene therapy was published in this series in October 2002. We now summarize the progress made since then and comment on the prospects for CF gene therapy over the next couple of years. Three clinical trials have been carried out, further supporting the proof-of-principle that gene transfer to the airway epithelium is feasible. Developments in viral and non-viral vectors, as well as recent alternative strategies such as gene repair, trans-splicing and stem cell therapy will be reviewed.

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