New Publication Describes Consortium Mixing Device

Friday, September 10th 2010

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A novel mixing device for the reproducible generation of nonviral gene therapy formulations, Davies et al., Biotechniques, 49, 666-668. A new publication by Davies et al, describes the development of a new mixing device to be used in out clinical trial programme.

The device, designed in house by the Consortium solves a major issue with the production of pDNA/GL67 liposomes, in that previously we have not had a standardised protocol for mixing the two components. Now with this simple gas driven device we can reproducibly produce formulations in a simple manner.

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Human airway liquid interface cultures transduced with a lentivirus expressing Luciferase.

 

A frozen vial of GL67A (left) and a frozen vial of pGM169 plasmid DNA (right)