Lentiviral Production in Wave Bioreactor (2015): Suspension cell culture is used to produce large quantities of Lentiviral vector. The rocking platform generates a 'wave' in the disposable bag which keeps cells in suspension.
Large scale lentivirus production in suspension culture.
Schematic diagram of the large human airways.
Pellets of DNA following precipitation.
A pellet of E.coli containing a plasmid expressing a pink fluorescent protein.
A CFTR Western blot, to confirm protein production in cell culture.
Mouse lung large airway (cell nuclei blue) transduced with an adenoviral vector (green).
A cake that only some of us got to enjoy!
E.coli from a large scale industrial production of our clinical trial plasmid pGM169.
A frozen vial of GL67A (left) and a frozen vial of pGM169 plasmid DNA (right)
Sheep lung parenchyma (cell nuclei blue) transduced with an adenoviral vector (green).
DNA fragments being cut from an agarose gel exposed to UV.
Light microscope image of a human airway liquid interface cultures. Dark patches are mucous.
Purifying mRNA from tissue samples.
Proposed 3D model of the CFTR protein.
Human airway liquid interface cultures transduced with a lentivirus expressing Luciferase.